ОНКОЛОГИЯ
и РАДИОЛОГИЯ
КАЗАХСТАНА
ISSN 1684-937X (печатная версия) [:en]ISSN 2521-6414 (Online),
ISSN 1684-937X (printed version)[:kz]ISSN 2521-6414 (Online),
ISSN 1684-937X (баспа нұсқасы) [:]
PHOTODYNAMIC THERAPY FOR CERVICAL CANCER: A LITERATURE REVIEW
N. Shanazarov1, G. Bariyeva1, N. Mussin2, R. Albayev1, A. Kaliyev2, E. Iztleuov2, S. Smailova1
1. Medical Centre Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, the Republic of Kazakhstan;
2. West Kazakhstan Marat Ospanov Medical University, Aktobe, the Republic of Kazakhstan
DOI: https://www.doi.org/10.52532/2521-6414-2023-4-70-56-63
UDC: 618.146-006.6:615.849.19
Year: 2023 issure: 70 number: 4 pages: 56-63
ABSTRACT
Relevance: Cervical cancer is a major public health problem worldwide, with human papillomavirus infection playing a vital role as a risk factor. Photodynamic therapy is a minimally invasive treatment for HPV-related cervical lesions that uses photosensitizers and light to selectively destroy abnormal cells.
The study aimed to comprehensively review the different types of molecules used in PDT to reduce the morbidity and mortality associated with cervical cancer.
Methods: A comprehensive search was conducted for all relevant articles investigating the efficacy and safety of PDT in the treatment of HPV-associated cervical cancer. PICO scores were determined for the review, and a literature search of the PubMed database was performed. An examination of the PubMed online database using keyword combinations identified 71 studies conducted between 2013 and 2023 that investigated using PDT to treat RSM cells.
This article reviews ongoing clinical trials examining the efficacy of PDT in treating low-grade squamous cell intraepithelial neoplasia and high-grade squamous cell intraepithelial lesions, as well as preclinical approaches using different molecules for PDT in cervical cancer
Results: Potential molecules for PDT are described, their advantages and disadvantages evaluated, and solutions to improve their compatibility with antitumor treatment are proposed. Our review shows that PDT is a promising therapeutic approach for diagnosing and treating HPV-related cervical lesions. At the same time, we observe that using different classes of dyes enhances the anticancer effects of PDT
Conclusion: Fullerene and ALA-PDT are potential leaders for more intensive use in PDT, which will further help reduce the global incidence and mortality from cervical cancer. However, further studies are needed to evaluate its long-term efficacy and safety.
Keywords: cervical cancer; human papillomavirus (HPV), Photodynamic therapy (PDT), Squamous intraepithelial neoplasia.
List of sources used:
- Arbyn M., Weiderpass E., Bruni L., de Sanjose S., Saraiya M., Ferlay J., Bray F. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis // Lancet Glob. Health. – 2020. – Vol. 8. – P. 191-203. https://doi.org/10.1016/S2214-109X(19)30482-6
- Okunade K.S. Human papillomavirus and cervical cancer // J. Obstet. Gynaecol. – 2020. – Vol. 40. – P. 602-608. https://doi.org/10.1080/01443615.2019.1634030
- Gilyadova A., Ishchenko A., Shiryaev A., Alekseeva P. , Efendiev K., Karpova R., Loshchenov M., Loschenov V., Reshetov I. Phototheranostics of Cervical Neoplasms with Chlorin e6 Photosensitizer // Cancers (Basel). – 2022. – Vol. 14. – P. 211. https://doi.org/10.3390/cancers14010211
- Matsui T., Tamoto R., Iwasa A., Mimura M., Taniguchi S., Hasegawa T., Sudo T., Mizuno H., Kikuta J., Onoyama I. Nonlinear optics with near-infrared excitation enable real-time quantitative diagnosis of human cervical cancers novel cancer diagnosis with nonlinear optical imaging // Cancer Res. – 2020. – Vol. 80. – P. 3745-3754. https://doi.org/10.1158/0008-5472.CAN-20-0348
- Feng Y., Tamadon A., Hsueh A.J.W. Imaging the ovary // Reprod. Biomed. Online. – 2018. – Vol. 36. – P. 584-593. https://doi.org/10.1016/j.rbmo.2018.02.006
- Yurttaş A.G., Sevim A.M., Çınar K., Atmaca G.Y., Erdoğmuş A., Gül A. The effects of zinc (II) phthalocyanine photosensitizers on biological activities of epitheloid cervix carcinoma cells and precise determination of absorbed fluence at a specific wavelength // Dyes Pigments. – 2022. – Vol. 198. – Art. no. e110012. https://doi.org/10.1016/j.dyepig.2021.110012
- Zhang S., Li Z., Xu Z., Tang Y., Duan C., Dai H., Dai X., Wei X., Liu Y., Xu C., Han B. Reactive oxygen species-based nanotherapeutics for head and neck squamous cell carcinoma // Mater. Des. – 2022. – Vol. 223. – Art. no. e111194. https://doi.org/10.1016/j.matdes.2022.111194
- Cang W., Gu L.Y., Hong Z.B., Wu A.Y., Di W., Qiu L.H. Effectiveness of photodynamic therapy with 5-aminolevulinic acid on HPV clearance in women without cervical lesions // Photodiagnosis Photodyn. Ther. – 2021. – Vol. 34. – Art. no. e102293. https://doi.org/10.1016/j.pdpdt.2021.102293
- Yu C., Li L., Wang S., Xu Y., Wang L., Huang Y., Hieawy A., Liu H., Ma J. Advances in nanomaterials for the diagnosis and treatment of head and neck cancers: A review // Bioact. Mater. – 2023. – Vol. 25. – P. 430-444. https://doi.org/10.1016/j.bioactmat.2022.08.010
- Wu A., Li Q., Ling J., Gu L., Hong Z., Di W., Qiu L. Effectiveness of photodynamic therapy in women of reproductive age with cervical high-grade squamous intraepithelial lesions (HSIL/CIN2) // Photodiagnosis Photodyn. Ther. – 2021. – Vol. 36. – Art. no. e102517. https://doi.org/10.1016/j.pdpdt.2021.102517
- Lan M., Zhao S., Liu W., Lee C.S., Zhang W., Wang P. Photosensitizers for Photodynamic Therapy // Adv. Healthc. Mater. – 2019. – Vol. 8. – Art. no. e1900132. https://doi.org/10.1002/adhm.201900132
- Zhang Y., Su Y., Tang Y., Qin L., Shen Y., Wang B., Zhou M., Zhou Y., Cao L., Zhang T., Zhang M. Comparative study of topical 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) and surgery for the treatment of high-grade vaginal intraepithelial neoplasia // Photodiagnosis Photodyn. Ther. – 2022. – Vol. 39. – P. 102958. https://doi.org/10.1016/j.pdpdt.2022.102958
- Guo W., Sun C., Jiang G., Xin Y. Recent Developments of Nanoparticles in the Treatment of Photodynamic Therapy for Cervical Cancer // Anticancer Agents Med. Chem. – 2019. – Vol. 19. – P. 1809-1819. https://doi.org/10.2174/1871520619666190411121953
- Schaffer P., Batash R., Ertl-Wagner B., Hofstetter A., Asna N., Schaffer M. Treatment of cervix carcinoma FIGO IIIb with Photofrin II as a radiosensitizer: a case report // Photochem. Photobiol. Sci. – 2019. – Vol. 18. – P. 1275-1279. https://doi.org/10.1039/c8pp00576a
- Vendette A.C.F., Piva H.L., Muehlmann L.A., de Souza D.A., Tedesco A.C., Azevedo R.B. Clinical treatment of intra-epithelia cervical neoplasia with photodynamic therapy // Int. J. Hypertherm. – 2020. – Vol. 37. – P. 50-58. https://doi.org/10.1080/02656736.2020.1804077
- Murakami H., Matsuya M., Adachi M., Itoh T., Shibata T., Nakayama T., Okazaki S., Itoh H., Kanayama N. Photodynamic Therapy Using Talaporfin Sodium for Cervical Intraepithelial Neoplasia // J. Japan Soc. Laser Surg. Med. – 2020. – Vol. 40. – P. 381-385. https://doi.org/10.2530/jslsm.jslsm-40_0063
- Yao H., Yan J., Zhou Z., Shen S., Wu Y., Liu P. , Zhang H., Wang X. A chlorin e6 derivative-mediated photodynamic therapy for patients with cervical and vaginal low-grade squamous intraepithelial lesions: a retrospective analysis // Transl. Biophoton. – 2022. – Vol. 55. – Art. no. e202200006. https://doi.org/10.1002/tbio.202200006
- Gierlich P., Mata A.I., Donohoe C., Brito R.M.M., Senge M.O., Gomes-da-Silva L.C. Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment // Molecules. – 2020. – Vol. 25. – P. 5317. https://doi.org/10.3390/molecules25225317
- Cheng M.H.Y., Overchuk M., Rajora M.A., Lou J.W.H., Chen Y., Pomper M.G., Chen J., Zheng G. Targeted Theranostic 111In/Lu-Nanotexaphyrin for SPECT Imaging and Photodynamic Therapy // Mol. Pharm. – 2022. – Vol. 19. – P. 1803-1813. https://doi.org/10.1021/acs.molpharmaceut.1c00819
- Choi M.C., Jung S.G., Park H., Lee S.Y., Lee C., Hwang Y.Y., Kim S.J. Photodynamic Therapy for the Management of Cervical Intraepithelial Neoplasia II and III in Young Patients and Obstetric Outcomes // Lasers Surg Med. – 2013. – Vol. 45. – P. 564–572. https://doi.org/10.1002/lsm.22187.
- Hillemanns P., Petry K.-U., Soergel P., Collinet P., Ardaens K., Gallwas J., Luyten A., Dannecker C. Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low-grade cervical intraepithelial neoplasia // Lasers Surg. Med. – 2014. – Vol. 46. – P. 456-461. https://doi.org/10.1002/lsm.22255
- Hillemanns P., Garcia F., Petry K.U., Dvorak V., Sadovsky O., Iversen O.-E., Einstein M.H. A randomized study of hexaminolevulinate photodynamic therapy in patients with cervical intraepithelial neoplasia ½ // Am. J. Obstet. Gynecol. – 2015. – Vol. 212. – P. 465.e1-465.e7. https://doi.org/10.1016/j.ajog.2014.10.1107
- Fu Y., Bao Y., Hui Y., Gao X., Yang M., Chang J. Topical photodynamic therapy with 5-aminolevulinic acid for cervical high-risk HPV infection // Photodiagnosis Photodyn. Ther. – 2016. – Vol. 13. – P. 29–33. https://doi.org/10.1016/j.pdpdt.2015.12.004
- Liu Z., Zheng H., Chen X., Qi N. Comparison of the efficacy of ALA and high-frequency electric ion operating on cervical intraepithelial neoplasia grade I // Int. J. Clin. Exp. Med. – 2016. – Vol. 9. – P. 16782–16786. https://e-century.us/files/ijcem/9/8/ijcem0019885.pdf
- Park Y.-K., Park C.-H. Clinical efficacy of photodynamic therapy // Obstet. Gynecol. Sci. – 2016. – Vol. 59 – P. 479. https://doi.org/10.5468/ogs.2016.59.6.479
- Inada N.M., Buzzá H.H., Leite M.F.M., Kurachi C., Trujillo J.R., de Castro C.A., Carbinatto F.M., Lombardi W., Bagnato V.S. Long Term Effectiveness of Photodynamic Therapy for CIN Treatment // Pharmaceuticals. – 2019. – Vol. 12. – P. 107. https://doi.org/10.3390/ph12030107
- Mizuno M., Mitsui H., Kajiyama H., Teshigawara T., Inoue K., Takahashi K., Ishii T., Ishizuka M., Nakajima M., Kikkawa F. Efficacy of 5-aminolevulinic acid and LED photodynamic therapy in cervical intraepithelial neoplasia: A clinical trial // Photodiagnosis Photodyn. Ther. – 2020. – Vol. 32. – P. 102004. https://doi.org/10.1016/j.pdpdt.2020.102004
- Li D., Zhang F., Shi L., Lin L., Cai Q., Xu Y. Treatment of HPV Infection-Associated Low-Grade Cervical Intraepithelial Neoplasia with 5-Aminolevulinic Acid-Mediated Photodynamic Therapy // Photodiagnosis Photodyn. Ther. – 2020. – Vol. 32. – P. 101974. https://doi.org/10.1016/j.pdpdt.2020.101974
- Zhang Y., Su Y., Tang Y., Qin L., Shen Y., Wang B., Zhou Y., Zhang M., Zhang T. Management of patients with positive margin after conization for high-grade cervical intraepithelial lesions // Lasers Surg. Med. – 2022. – Vol. 54. – P. 1099-1106. https://doi.org/10.1002/lsm.23585.
- Chen Y., Xu Y., Zhang Z., Xiong Z., Wu D. 5-aminolevulinic acid-mediated photodynamic therapy effectively ameliorates HPV-infected cervical intraepithelial neoplasia // Am. J. Transl. Res. – 2022. – Vol. 14. – P. 2443–2451.
- de Matos R.P. A., Calmon M.F., Amantino C.F., Villa L.L., Primo F.L. Tedesco A.C., Rahal P. Effect of Curcumin-Nanoemulsion Associated with Photodynamic Therapy in Cervical Carcinoma Cell Lines // Biomed. Res. Int. – 2018. – Art. no. e4057959. https://doi.org/10.1155/2018/4057959
- He G., Mu T., Yuan Y., Yang W., Zhang Y., Chen Q., Bian M., Pan Y., Xiang Q., Chen Z., Sun A. Effects of Notch Signaling Pathway in Cervical Cancer by Curcumin Mediated Photodynamic Therapy and Its Possible Mechanisms in Vitro and in Vivo // J. Cancer. – 2019. – Vol. 10. – P. 4114-4122. https://doi.org/10.7150/jca.30690
- Abrahamse H, Hamblin M.R. New photosensitizers for photodynamic therapy // Biochem J. – 2016. – Vol. 473(4). – P. 347-364. https://doi.org/10.1042/BJ20150942
- Chan B.C.L., Dharmaratne P., Wang B., Lau K.M., Lee C.C., Cheung D.W.S., Chan J.Y.W., Yue G.G.L., Lau C.B.S., Wong C.K., Fung K.P., Ip M. Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo // Pharmaceutics. – 2021. – Vol. 13. – P. 1399. https://doi.org/10.3390/pharmaceutics13091399
- Fan H.M., Chen S., Du Z., Yan T., Alimu G., Zhu L.J., Ma R., Alifu N., Zhang X.L. New indocyanine green therapeutic fluorescence nanoprobes assisted high-efficient photothermal therapy for cervical cancer // Dyes Pigments. – 2022. – Vol. 200. – Art. no. e110174. https://doi.org/10.1016/j.dyepig.2022.110174
- Ghorbani F., Attaran-Kakhki N., Sazgarnia A. The synergistic effect of photodynamic therapy and photothermal therapy in the presence of gold-gold sulfide nanoshells conjugated Indocyanine green on HeLa cells // Photodiagnosis Photodyn. Ther. – 2017. – Vol. 17. – P. 48-55. https://doi.org/10.1016/j.pdpdt.2016.10.002
- Yu J., Hsu C.H., Huang C.C., Chang P. Y. Development of therapeutic Au-methylene blue nanoparticles for targeted photodynamic therapy of cervical cancer cells // ACS Appl. Mater. Interfaces. – 2015. – Vol. 7. – P. 432-441. https://doi.org/10.1021/am5064298
- Chaturvedi P. K., Kim Y.-W., Kim S.S., Ahn W.S. Phototoxic effects of pyropheophorbide-a from chlorophyll-a on cervical cancer cells // J. Porphyr. Phthalocyanines. – 2014. – Vol. 18. – P. 182-187. http://dx.doi.org/10.1142/S1088424613501034
- Chaturvedi P.K., Kim Y.W., Kim S.S., Ahn W.S. Phototoxic effects of pyropheophorbide-a from chlorophyll-a on cervical cancer cells // J. Porphyr. Phthalocyanines. – 2014. – Vol. 18. – P. 182-187. https://doi.org/10.1142/S1088424613501034
- Alam M.B., Minocha T., Yadav S.K., Parmar A.S. Therapeutic Potential of Chlorophyll Functionalized Carbon Quantum Dots against Cervical Cancer // Chemistry select. – 2022. – Vol. 7. – Art. no. e202204562. https://doi.org/10.1002/slct.202204562
- Kiriyanthan R.M., Sharmili S.A., Balaji R., Jayashree S., Mahboob S., Al-Ghanim K.A., Al-Misned F., Ahmed Z., Govindarajan M., Vaseeharan B. Photocatalytic, antiproliferative and antimicrobial properties of copper nanoparticles synthesized using Manilkara zapota leaf extract: A photodynamic approach // Photodiagnosis Photodyn. Ther. – 2020. – Vol. 32. – Art. no. e102058. https://doi.org/10.1016/j.pdpdt.2020.102058
- Pratavieira S., Uliana M.P., Dos Santos Lopes N.S., Donatoni M.C., Linares D.R., de Freitas Anibal F., de Oliveira K.T., Kurachi C., de Souza C.W.O. Photodynamic therapy with a new bacteriochlorin derivative: Characterization and in vitro studies // Photodiagnosis Photodyn Ther. – 2021. – Vol. 34. – Art. no. e102251. https://doi.org/10.1016/j.pdpdt.2021.102251
- Huang Y.Y., Sharma S.K., Yin R., Agrawal T., Chiang L.Y., Hamblin M.R. Functionalized fullerenes in photodynamic therapy // J. Biomed. Nanotechnol. – 2014. – Vol. 10. – P. 1918-1936. https://doi.org/10.1166/jbn.2014.1963
- Hamblin M.R. Fullerenes as photosensitizers in photodynamic therapy: pros and cons // Photochem. Photobiol. Sci. – 2018. – Vol. 17(11). – P. 1515-1533. https://doi.org/10.1039/c8pp00195b
- Navasconi T.R., Dos Reis V.N., Freitas C.F., Pereira P.C.S., Caetano W., Hioka N., Lonardoni M.V.C., Aristides S.M.A., Silveira T.G.V. Photodynamic Therapy With Bengal Rose and Derivatives Against Leishmania amazonensis // J. Lasers Med. Sci. – 2017. – Vol. 8(1). – P. 46-50. https://doi.org/10.15171/jlms.2017.09
- Baghban N., Khoradmehr A., Nabipour I., Tamadon A., Ullah M. The potential of marine-based gold nanomaterials in cancer therapy: a mini-review // Gold Bulletin. – 2022. – Vol. 55. – P. 53-63. https://doi.org/10.1007/s13404-021-00304-6
- Baghban N., Khoradmehr A., Afshar A., Jafari N., Zendehboudi T., Rasekh P., Abolfathi L.G., Barmak A., Mohebbi G., Baspakova A., Kaliyev A.A.? Mussin N.M., Azari H., Assadi M., Nabipour I. MRI Tracking of Marine Proliferating Cells In Vivo Using Anti-Oct4 Antibody-Conjugated Iron Nanoparticles for Precision in Regenerative Medicine // Biosensors (Basel). – 2023. – Vol. 13. – P. 268. https://doi.org/10.3390/bios13020268
- Afshar A., Zare M., Farrar Z., Hashemi A., Baghban N., Khoradmehr A., Habibi H., Nabipour I., Shirazi R., Behzadi M.A. Exosomes of mesenchymal stem cells as nano-cargos for anti-SARS-CoV-2 asRNAs // Modern Med. Lab. J. – 2021. – Vol. 4. – P. 11-18. https://modernmedlab.com/article-1-94-en.html
- Salehpour A., Balmagambetova S., Mussin N., Kaliyev A., Rahmanifar F. Mesenchymal stromal/stem cell-derived exosomes and genitourinary cancers: A mini-review // Front. Cell. Dev. Biol. – 2022. – Vol. 10. – Art. no. e1115786. – https://doi.org/10.3389/fcell.2022.1115786
- Nowzari F., Wang H., Khoradmehr A., Baghban M., Baghban N., Arandian A., Muhaddesi M., Nabipour I., Zibaii M.I., Najarasl M., Taheri P., Latifi H., Tamadon A. Three-Dimensional Imaging in Stem Cell-Based Researches // Front. Vet. Sci. – 2021. – Vol. 8. – Art. no. e657525. https://doi.org/10.3389/fvets.2021.657525
- Unanyan A., Pivazyan L., Davydova J., Murvatova K., Khrapkova A., Movsisyan R., Ishchenko A., Ishchenko A. Efficacy of photodynamic therapy in women with HSIL, LSIL and early stage squamous cervical cancer: a systematic review and meta-analysis // Photodiagnosis Photodyn. Ther. – 2021. – Vol. 36. – P. 102530. https://doi.org/10.1016/j.pdpdt.2021.102530
- Hodgkinson N., Kruger C.A., Mokwena M., Abrahamse H. Cervical cancer cells (HeLa) response to photodynamic therapy using a zinc phthalocyanine photosensitizer // J. Photochem. Photobiol. B. – 2017. – Vol. 177. – P. 32-38. https://doi.org/10.1016/j.jphotobiol.2017.10.004
Error: Contact form not found.