F.K. Rakhimbekova ^1,2, M.G. Orazgaliyeva ³, T.G. Goncharova ³

1. «Asfendiayrov Kazakh National Medical University» NCJSC, Almaty, the Republic of Kazakhstan;
2. «Satbayev University» NCJSC, Almaty, the Republic of Kazakhstan;
3. «Kazakh Institute of Oncology and Radiology» JSC, Almaty, the Republic of Kazakhstan

DOI: https://www.doi.org/10.52532/2663-4864-2023-3-69-11-15

UDC: 616-006:628.3(574.54)

Year: 2023 issure: 69 number: 3 pages: 11-15

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ABSTRACT

Relevance: In 2004-2013, the cumulative cancer incidence was about 200 cases per 100 thousand in Kazakhstan, while in the disaster area of Aral Sea – about 225 cases per 100 thousand. For comparison, cancer incidence in the prosperous region of Karaganda was 140 cases per 100,000 population. As of 2021, the incidence of colorectal cancer in Kyzylorda was 17.73 compared to 5.81 per 100,000 population in 2015.
Factors of the surrounding macro- and microenvironment are trigger factors for tumor initiation. Salt deposits of the dried Aral Sea in the form of solonchaks spread to the territory of the entire Kyzylorda region. Pesticides and process water have been discharged into rivers for many years, which has led to the accumulation of heavy metal salts in water and soil on the banks of the rivers and in the place of the dried-up Aral Sea, which in turn can affect the increase in cancer incidence.
The study aimed to study the dependence of cancer incidence on water pollution by ions of chlorine and lead in open water bodies in the Kyzylorda region.
Methods: Analysis of cancer incidence in 2021 by localization: intestines, stomach, sarcomas, lungs, and melanomas in the Kyzylorda region. Determination of the content of chlorine ions by titration with silver nitrate, spectrophotometric determination of lead ions in the open water sources. Comparative correlation analysis of the concentration of chlorine ions and lead with cancer incidence in this region.
Results: The maximum permissible chlorine and lead ions concentrations in all studied open water sources of the Kyzylorda region exceeded the norm by 1.024-20.26 times and 1.4-14.1 times, respectively. The presence of chlorides in the water increased intestine cancer incidence by 17% with an approximation certainty of 0.38. The presence of lead in water increased the incidence of melanomas by 22%, with an approximation certainty of 0.79. The correlation coefficient was r=0.618; p=0.07 for exceeding chlorides’ MPC and bowel cancer incidence.
Conclusion: Heavy metals like lead in water samples in regions with increased cancer incidence indicate a co-dependent relationship of these factors. Pollutants such as chlorides and lead increase intestine cancer and melanoma incidence.
Keywords: Kyzylorda, melanoma, lung cancer, intestine cancer, chloride ions, lead ions.

List of sources used:

1. Pulumati A., Pulumati A., Dwarakanath B.S., Verma A., Papineni R.V.L. Technological advancements in cancer diagnostics: Improvements and limitations // Cancer Rep (Hoboken). – 2023. – 6(2):e1764. https://doi.org/10.1002/cnr2.1764
2. McCain J. The MAPK (ERK) Pathway: Investigational Combinations for the Treatment Of BRAF-Mutated Metastatic Melanoma // Pharmacy and Therapeutics. – 2013. – 8(2):96-108. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628180/
3. Tagliabue E. Special Issue: Micro- and Macro-Environmental Factors in Solid Cancers // Cells. – 2021. – 27;10(2):247. https://doi.org/10.3390/cells10020247
4. Al-Zoughbi W., Huang J., Paramasivan G.S., Till H., Pichler M., Guertl-Lackner B., Hoefler G. Tumor macroenvironment and metabolism // Semin Oncol. – 2014. – Vol. 41(2). – P. 281-295. https://doi.org/10.1053/j.seminoncol.2014.02.005
5. Morales M.E., Derbes R.S., Ade C.M., Ortego J.C., Stark J., Deininger P.L., Roy-Engel A.M. Heavy Metal Exposure Influences Double Strand Break DNA Repair Outcomes // PLoS One. – 2016. – Vol. 11(3). – P. e0151367. https://doi.org/10.1371/journal.pone.0151367
6. Balali-Mood M., Naseri K., Tahergorabi Z., Khazdair M. R., Sadeghi M. Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic // Front. Pharmacol. – 2021. – Vol. 12. https://doi.org/10.3389/fphar.2021.643972
7. Wang X.Q., Terry P.D., Yan H. Review of salt consumption and stomach cancer risk: epidemiological and biological evidence // World J. Gastroenterol. – 2009. – Vol. 15(18). – P. 2204-2213. https://doi.org/10.3748/wjg.15.2204
8. Romaniuk А., Lyndin M., Sikora V., Lyndina Y., Romaniuk S., Sikora K. Heavy metals effect on breast cancer progression // J. Occup. Med. Toxicol. – 2017. – Vol. 12. – P. 32. https://doi.org/10.1186/s12995-017-0178-1
9. Matés J.M., Segura J.A., Alonso F.J., Márquez J. Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms // Free Rad. Biol. Med. – 2010. – Vol. 49(9). – P. 1328-1341. https://doi.org/10.1016/j.freeradbiomed.2010.07.028
10. Grabish B. Dry tears of the Aral // UN Chronicle. – 1999. 1. https://www.un.org/en/chronicle/article/dry-tears-aral. 20.06.2023
11. Zhupankhan A., Khaibullina Z., Kabiyev Y., Persson K.M., Tussupova K. Health Impact of Drying Aral Sea: One Health and Socio-Economical Approach // Water. – 2021. – Vol. 13(22). – P. 3196. https://doi.org/10.3390/w13223196
12. Mamyrbayev A., Djarkenov T., Dosbayev A., Dusembayeva N., Shpakov A., Umarova G., Drobchenko Y., Kunurkulzhayev T., Zhaylybaev M., Isayeva G. The Incidence of Malignant Tumors in Environmentally Disadvantaged Regions of Kazakhstan // Asian Pac. J. Cancer Prev. – 2016. – Vol. 17(12). – P. 5203-5209. https://doi.org/10.22034/APJCP.2016.17.12.5203
13. Hong Y., Zhu Z., Liao W., Yan Z., Feng C., Xu D. Freshwater Water-Quality Criteria for Chloride and Guidance for the Revision of the Water-Quality Standard in China // Int J Environ Res Public Health. – 2023. – Vol. 20(4). – P. 2875. https://doi.org/10.3390/ijerph20042875
14. CDC. Lead in drinking water. https://www.cdc.gov/nceh/lead/prevention/sources/water.htm#:~:text=EPA%20has%20set%20the%20maximum,even%20at%20low%20exposure%20levels. 20.06.2023
15. Morris R.D. Drinking water and cancer // Environ. Health Perspect. – 1995. – Vol. 103 (Suppl 8). -P. 225-231. https://doi.org/10.1289/ehp.95103s8225
16. Li L., Haoran Y., Xiaocang X. Effects of Water Pollution on Human Health and Disease Heterogeneity: A Review // Front Environ. Sci. – 2022. – Vol. 10. https://doi.org/10.3389/fenvs.2022.880246
17. CDC. Cancer. https://www.cdc.gov/chronicdisease/resources/publications/factsheets/cancer.htm. 20.06.2023
18. El-Tawil A.M. Colorectal cancer and pollution // World J. Gastroenterol. – 2010. – Vol. 16(28). – P. 3475-3477. https://doi.org/10.3748/wjg.v16.i28.3475
19. Clapp R.W., Jacobs M.M, Loechler E.L. Environmental and occupational causes of cancer: new evidence 2005-2007 // Rev. Environ. Health. – 2008. – Vol. 23(1). – P. 1-37. https://doi.org/10.1515/reveh.2008.23.1.1
20. PubChem. National Library of Medicine. Gastric Acid Production. https://pubchem.ncbi.nlm.nih.gov/pathway/PathBank:SMP0119381
21. Chen T.J., He H.L., Shiue Y.L., Yang C.C., Lin L.C., Tian Y.F., Chen S.H. High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy // Int. J. Med. Sci. – 2018. – Vol. 15(11). – P. 1171-1178. https://doi.org/10.7150/ijms.26685