Ways to improve the diagnostics and detection of cervical cancer development and recurrence risk
K.N. Tazhibayeva1-3, A.D. Sadykova3, D.T. Tasboltaeva1, A.N. Ormanov1,2, G.E. Kaldygozova2
1. Shymkent City Oncological Dispensary, Shymkent, the Republic of Kazakhstan;
2. Khoja Akhmet Yassawi International Kazakh-Turkish University, Shymkent, the Republic of Kazakhstan;
3. SAl-Farabi Kazakh National University, Almaty, the Republic of Kazakhstan
Год: 2021 выпуск: 62 номер: 4 страницы: 24-27
Relevance: Cervical cancer is the fourth leading cause of female death and the third most common female cancer worldwide.
The purpose of the study was to determine risk factors and time to progression and recurrence in patients with cervical cancer after complex treatment (neoadjuvant chemotherapy + radical hysterectomy + combined radiation therapy).
Materials and methods: This retrospective study involved female patients with stage IB-IIA cervical cancer registered at Shymkent city oncological dispensary in 2011-2021 (n=883). All patients underwent radical hysterectomy with pelvic lymph node dissection. The patients
were selected who underwent radiation therapy of the lower pelvis at a dose of ≥40 g. The age-, stage-, and tumor morphological structure-dependent survival factors and recurrence risk were analyzed during the research decade.
Results: Direct correlation of the disease stage and the recurrence period was established. The progression was most often 5 to 6 months after treatment. 68.7% of progression and 63.1% of recurrences occurred in the first year and a half after the end of treatment, so this period
is considered the most “dangerous” regarding the recurrence risk. 5.3% of patients had a recurrence 19 to 24 months after treatment, 31.5%
– after more than two years.
Conclusions: In this research, cervical cancer progressed in 74 (10.6%) out of 883 women and recurred in 19 (3.0%). The recurrence was most frequent in women aged 45-50 years (28.4%) and 50-60 years (26.3%).
Ключевые слова: cervical cancer, risk factor, progression, recurrence.
Ссылка: K.N. Tazhibayeva, A.D. Sadykova, D.T. Tasboltaeva, A.N. Ormanov, G.E. Kaldygozova. Ways to improve the diagnostics and detection of cervical cancer development and recurrence risk. Oncology and Radiology of Kazakhstan, 2021, 62 (4), 24-27.