Molecular genetic testing for BRAF V600 gene mutations in melanoma in the Republic of Kazakhstan
D.R. KAIDAROVA1, Z.D. DUSHIMOVA1, M.G. ORAZGALIYEVA1, O.V. SHATKOVSKAYA1, S.T. ALIEVA1, S.O. OSSIKBAYEVA1
1.Kazakh Institute of Oncology and Radiology, Almaty, the Republic of Kazakhstan
Год: 2021 выпуск: 59 номер: 1 страницы: 20-24
Relevance: Along with other diagnostic methods, all current recommendations and protocols for malignant tumors’ diagnostics and treatment require mandatory molecular genetic testing at the initial diagnosis and in case of disease progression.
The discovery of the BRAF gene mutation in skin melanoma allows the treatment with tyrosine kinase inhibitors, so-called BRAF inhibitors. This increases the probability of tumor response by half and opens up new therapeutic options.
The study aimed to identify the BRAF V600E gene mutation frequency in patients with stage III-IV melanoma in the Republic of Kazakhstan to determine the need for targeted therapy.
Results: 2251 persons are currently registered with melanoma in the Republic of Kazakhstan, with 355 new primary melanoma cases in 2019. Of them, 54% were diagnosed at stages III-IV and were subject to molecular genetic testing. 278 of 2251 patients were sent for BRAF mutations testing. The mutations were detected in 105 (37.7%) patients.
Conclusion: The introduction of molecular genetic testing for malignant neoplasms under the Comprehensive Cancer Control Plan framework for 2018-2022 will increase the use of molecular genetic methods in the Republic of Kazakhstan. Molecular genetic testing is an important step in diagnosing melanoma and choosing the appropriate therapy to personalize cancer treatment.
Ключевые слова: melanoma, molecular genetic testing (MGT), BRAF V600E gene mutations, personalized approach, targeted therapy.
Ссылка: D.R. Kaidarova, Z.D. Dushimova, M.G. Orazgaliyeva, O.V. Shatkovskaya, S.T. Alieva, S.O. Ossikbayeva. Molecular genetic testing for BRAF V600 gene mutations in melanoma in the Republic of Kazakhstan. Oncology and Radiology of Kazakhstan, 2021, 59 (1), 20-24.